Formulation and Evaluation of Liposome by Thin Film Hydration Method

Liposomes are the most advance formulation for targeting and controlled drug delivery system. These liposomes generally administered by intra-venous route. In this work liposome was prepared using thin film hydration method. The formulated is evaluated or characterised zeta sizer, Encapsulation efficiency, Entrapment vitro release. Main things which used of Diclofenac sodium, it having anti-inflammatory anti-pyretic effect. sodium several adverse effects, such as depression renal function, Liver failure repeated administration, Local mucosal irritation, gastritis. To avoid effect incorporate in liposomal formulation. By formulating formulation, bioavailability increase. conventional dosage form diclofenac 50℅. But final result includes that shows more sustained prolong activity.
 Keywords: Liposome, Anti-inflammatory activity.